JOSEPH W. HESS, M.D.; RODERICK P. MACDONALD, PH.D; RICHARD J. FREDERICK, M.S.; ROBERT N. JONES, M.D.; JOANN NEELY, M.D.; DAVID GROSS, M.D.
Serum enzyme studies have come to occupy an increasingly important place in clinical medicine. Accurate interpretation of elevated serum enzyme activity may be complicated, however, because many of the serum enzymes used as diagnostic aids in clinical medicine are found in several types of tissues. If a clinical situation is simple and only one type of tissue is diseased, then interpretation of the test results may not pose a problem. If, on the other hand, more than one tissue is affected, the physician may have difficulty interpreting an elevation if he is aware of multiple organ disease; or he may
HESS JW, MACDONALD RP, FREDERICK RJ, et al. Serum Creatine Phosphokinase (CPK) Activity in Disorders of Heart and Skeletal Muscle. Ann Intern Med. 1964;61:1015–1028. doi: 10.7326/0003-4819-61-6-1015
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Published: Ann Intern Med. 1964;61(6):1015-1028.
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