ARTHUR SAWITSKY, M.D.; JAVID RUOHANI, M.D.; ROBERT N. LEVY, M.D.
The adenine analog 6-mercaptopurine is an inhibitor of growth in various microbiological systems (1), of mouse sarcoma 180 (2), and of cell growth in several types of acute leukemia in mice (3). The original report by Burchenal and his colleagues (4) that 6-mercaptopurine was effective as an antileukemic agent in human acute and chronic myeloid leukemia has been amply confirmed (5), and the drug is now an accepted agent for treatment of these diseases. Toxic reactions to the drug are frequent, the most common being excessive hematologic cellular depression, nausea, vomiting, and gastrointestinal mucosal ulceration (5). Less frequently a cholangiolitic
SAWITSKY A, RUOHANI J, LEVY RN. Drug Fever Produced by Six-mercaptopurine. Ann Intern Med. ;61:1116–1121. doi: 10.7326/0003-4819-61-6-1116
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Published: Ann Intern Med. 1964;61(6):1116-1121.
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