MORRIS E. MISSAL, M.D., F.A.C.P.; JAMES A. ROBINSON, M.D.; RONALD W. TATUM, M.D.
The syndrome of inferior vena caval obstruction may present with unusual and varied pathological conditions: The syndrome may resemble or be associated with such conditions as congestive heart failure, cirrhosis of the liver, intra-abdominal malignancy, or renal disease, including the nephrotic syndrome. It must be considered in the differential diagnosis of ascites, hepatosplenomegaly, generalized amyloidosis, collagen disorders, and malabsorption syndrome as well as many other seemingly unrelated disorders. Pulmonary embolism should alert one to its possible presence.
Although familiar to physicians since the nineteenth century and well-described by William Osler (1) in 1879, the diagnosis of inferior vena caval obstruction
MISSAL ME, ROBINSON JA, TATUM RW. Inferior Vena Cava Obstruction: Clinical Manifestations, Diagnostic Methods, and Related Problems. Ann Intern Med. 1965;62:133–161. doi: 10.7326/0003-4819-62-1-133
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Published: Ann Intern Med. 1965;62(1):133-161.
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