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Macfarlane begins this informative and well-written volume with an eloquent review of our understanding of fibrinolysis from Hunter's observations in 1794 to the present day. Reasons for the controversy over the existence of the fibrinolytic factor, proactivator, are discussed. In subsequent papers fibrinolysis is reviewed from many different aspects. The value of various assay procedures is compared (MacKay, Fearnley, Flute), as are methods of purifying components of the fibrinolytic system (MacKay). Evidence is presented that plasminogen activator exists in, and is released from, the intima of veins in the normal organism (Stafford, Flute, Todd, Warren). Howell discusses inhibition of fibrinolysis
Fibrinolysis.. Ann Intern Med. 1965;62:184–185. doi: https://doi.org/10.7326/0003-4819-62-1-184
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Published: Ann Intern Med. 1965;62(1):184-185.
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