HOWARD M. SILBY, M.D.; ROGER FARBER, M.D.; CORNELIUS J. O'CONNELL, M.D.; JULIAN ASCHER, M.D.; EDWARD J. MARINE, M.D.
Arthritis has been described as an occasional complication of several viral diseases. However, to the authors' knowledge, the isolation of a specific virus from human synovial fluid in such cases has not been reported previously. The present report documents a case of acute monarticular arthritis after smallpox vaccination in which vaccinia virus was recovered from the synovial fluid.
E. J. (BGH 293446), a 65-year-old Negro female, was admitted to the Buffalo General Hospital on June 25, 1963, because of fever and a painful swelling of the right knee. Twelve days previously, at her request, she had been vaccinated
SILBY HM, FARBER R, O'CONNELL CJ, et al. Acute Monarticular Arthritis After Vaccination: Report of a Case with Isolation of Vaccinia Virus from Synovial Fluid. Ann Intern Med. 1965;62:347–350. doi: https://doi.org/10.7326/0003-4819-62-2-347
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Published: Ann Intern Med. 1965;62(2):347-350.
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