C. LOWELL EDWARDS, M.D.; NAZARETH GENGOZIAN, PH.D.
Macroglobulins are a group of serum proteins, frequently referred to as paraproteins, having a molecular weight of at least one million and a sedimentation constant of more than 15 (usually 19 to 20) Svedberg units. Among the macroglobulins of clinical importance are the macroglobulin of Waldenström, the rheumatoid factor, some isohemagglutinins and Rh antibodies, some cryoglobulins, and cold agglutinins. In 1957, Deutsch and Morton (1) reported that macroglobulins could be depolymerized in vitro by incubation with certain mercaptans. It was later demonstrated that upon depolymerization the physiologic or immunologic properties of the proteins were lost even when there was some
EDWARDS CL, GENGOZIAN N. Auto-immune Hemolytic Anemia Treated with d-Penicillamine: Report of a Case. Ann Intern Med. ;62:576–579. doi: 10.7326/0003-4819-62-3-576
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Published: Ann Intern Med. 1965;62(3):576-579.
Hematology/Oncology, Red Cell Disorders.
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