HARVEY C. GONICK, M.D.; MILTON E. RUBINI, M.D.; IRENE O. GLEASON, M.D.; SHELDON C. SOMMERS, M.D.
Progressive renal failure is a frequent cause of death in gout, the incidence varying from 22 to 25% in reported series (1, 2). Traditionally, the kidney lesion has been described as consisting of a combination of pyelonephritis, advanced arterio-nephrosclerosis, and tophus formation (2-6). Only the last finding, however, is thought to be diagnostic (1). It has been suggested from studies of autopsy material that the renal lesions stem from deposition of urates in collecting tubules, with resultant obstruction, atrophy of the more proximal tubules, and secondary necrosis and fibrosis (3-6). The associated interstitial inflammatory process has been attributed to a
GONICK HC, RUBINI ME, GLEASON IO, et al. The Renal Lesion in Gout. Ann Intern Med. 1965;62:667–674. doi: https://doi.org/10.7326/0003-4819-62-4-667
Download citation file:
Published: Ann Intern Med. 1965;62(4):667-674.
Gout, Nephrology, Rheumatology.
Results provided by:
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use