HERBERT A. SELENKOW, M.D., F.A.C.P.; ANTONIO M. GARCIA, M.D.; EDWARD B. BRADLEY, M.D.
In the past, clinical observations on the effects of iodide in diverse thyroidal diseases have appeared quite paradoxic. For example, high doses are known to produce both goiter and hypothyroidism in some individuals, whereas in others, iodide is used therapeutically to correct goiter as well as hypothyroidism. In Graves' disease, iodide is given to inhibit excess thyroid hormone synthesis and thus ameliorate thyrotoxicosis; yet in some iodide-deficient goiters, it has been known to enhance thyroid hormone secretion to induce thyrotoxicosis (Jod-Basedow). These seemingly contradictory phenomena have been studied extensively and reviewed (1) but still remain enigmatic.
The role of iodide
SELENKOW HA, GARCIA AM, BRADLEY EB. An Autoregulatory Effect of Iodide in Diverse Thyroid Disorders. Ann Intern Med. 1965;62:714–726. doi: 10.7326/0003-4819-62-4-714
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Published: Ann Intern Med. 1965;62(4):714-726.
Endocrine and Metabolism, Thyroid Disorders.
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