HANS U. WESSEL, M.D.; HERBERT M. SOMMERS, M.D.; DAVID W. CUGELL, M.D.; MILTON H. PAUL, M.D.
Chronic visceral schistosomiasis may lead to two distinct cardiopulmonary sequelae:  cor pulmonale due to obstructive hypertensive pulmonary vascular disease and  a cyanotic syndrome manifested by cyanosis, clubbing, arterial hemoglobin unsaturation for oxygen (oxygen unsaturation), and normal pulmonary artery pressures.
Whereas discrete pulmonary lesions are commonly found in patients with schistosomiasis, the incidence of cor pulmonale is low and varies from 0.8 to 5.5% in autopsy material from different endemic areas (1-3). The pulmonary vascular lesions are due to embolization of schistosomal eggs, causing an allergic arteritis and paravascular granulomatous reaction. In Manson's schistosomiasis, extensive pulmonary lesions occur only
WESSEL HU, SOMMERS HM, CUGELL DW, PAUL MH. Variants of Cardiopulmonary Manifestations of Manson's Schistosomiasis: Report of Two Cases. Ann Intern Med. ;62:757–766. doi: 10.7326/0003-4819-62-4-757
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Published: Ann Intern Med. 1965;62(4):757-766.
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