P. J. CANNON, M.D.; H. O. HEINEMANN, M.D.; M. S. ALBERT, M.D.; J. H. LARAGH, M.D.; R. W. WINTERS, M.D.
Systemic alkalosis has been observed (1) after diuresis of patients with ethacrynic acid, a new potent oral diuretic. In the present study, metabolic balance studies were performed on four patients with congestive heart failure in order to define the pathogenesis of this alkalosis. The results indicate that in these patients with edema, the acid-base disturbance observed after ethacrynic acid therapy resulted primarily from a large acute contraction of the extracellular fluid space produced by the large saluresis and diuresis caused by the drug. Urinary losses of relatively bicarbonate free fluid caused the extracellular space to contract around the initial extracellular
CANNON PJ, HEINEMANN HO, ALBERT MS, LARAGH JH, WINTERS RW. "Contraction" Alkalosis After Diuresis of Edematous Patients with Ethacrynic Acid. Ann Intern Med. ;62:979–990. doi: 10.7326/0003-4819-62-5-979
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Published: Ann Intern Med. 1965;62(5):979-990.
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