RICHARD A. HOLMES, M.D.; NORMAN H. ENGBRING, M.D.; WILLIAM W. ENGSTROM, M.D.
Since publication of C. H. Parry's original description of hyperthyroidism in 1825 (1), little attention has been given to neonatal hyperthyroidism until recently. White, in 1912, recorded the first case (2), and since that time less than 30 cases have been added. The infrequent occurrence generally is attributed either to the infertility or to the rarity of viable pregnancies in thyrotoxic women. Hyperthyroidism in these instances is almost invariably a part of Graves' disease. Although the pathogenesis of Graves' disease remains obscure, a long-acting thyroid stimulating substance (LATS), initially described by Adams (3), has been implicated as a possible etiological
HOLMES RA, ENGBRING NH, ENGSTROM WW. Neonatal Graves' Disease. Ann Intern Med. 1965;62:1008–1013. doi: 10.7326/0003-4819-62-5-1008
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Published: Ann Intern Med. 1965;62(5):1008-1013.
Endocrine and Metabolism, Thyroid Disorders.
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