Robert H. Seller, M.D.; Osvaldo Ramirez-Muxo, M.D.; Albert N. Brest, M.D., F.A.C.P.; John H. Moyer III, M.D., F.A.C.P.
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Increased vascular smooth muscle tone and the associated changes in transmembrane potential are thought to be a major factor in the development and maintenance of hypertension. Magnesium affects transmembrane potential, and hypomagnesemia has been reported in essential hypertension and primary aldosteronism associated with hypertension.
To determine the significance of magnesium metabolism in the pathogenesis and treatment of hypertension serum and erythrocytic magnesium, calcium, sodium, and potassium as well as serum urea nitrogen, creatinine, phosphorus, chloride, and carbon dioxide were determined in 20 normal subjects and in 16 hypertensive patients before and after 12 weeks of hydrochlorothiazide therapy. Atomic absorption spectroscopy
Seller RH, Ramirez-Muxo O, Brest AN, Moyer JH. Magnesium Metabolism in Hypertensive Cardiovascular Disease.. Ann Intern Med. ;62:1072. doi: 10.7326/0003-4819-62-5-1072_1
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Published: Ann Intern Med. 1965;62(5):1072.
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