Howard Rasmussen, M.D.
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Two of the most widely held theories of hormone action are: (1) hormones act by altering the transport of substances across membranes and (2) hormones act by altering genetic expression within cells. Much recent work suggests that one of the most basic effects of parathyroid hormone is upon the transport of calcium, magnesium, phosphate, and potassium across cellular and subcellular membranes. The addition of hormone to isolated mitochondria in vitro leads to a redistribution of all these ions across the mitochondrial membrane. This ionic redistribution is similar to that which the hormone produces across the renal tubule. This effect of
Rasmussen H. The Action of Parathyroid Hormone.. Ann Intern Med. 1965;62:1074. doi: https://doi.org/10.7326/0003-4819-62-5-1074_2
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Published: Ann Intern Med. 1965;62(5):1074.
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