Robert H. Williams, M.D., F.A.C.P.
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Recent investigations have suggested that the majority of instances of diabetes are inherited and that in the early phases of the disease there is an excess of assayable insulin in the plasma, but a decreased effectiveness, which is attributed to counter-insulin factors. One of these consists of the synalbumin factor, which may compete with insulin for its binding sites. There is an increase of this material even in the prediabetic phase and especially in overt diabetes. Somatotropin, catecholamines, glucosteroids, glucagon, and other hormones greatly influence insulin secretion and actions. The liver apparently plays an important role in the complexing of
Williams RH. The Alfred Stengel Memorial Lecture: Recent Advances Relative to Diabetes.. Ann Intern Med. 1965;62:1074. doi: https://doi.org/10.7326/0003-4819-62-5-1074_3
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Published: Ann Intern Med. 1965;62(5):1074.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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