Martin A. Rizack, M.D., Ph.D., F.A.C.P.
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The activity of triglyceride lipase present in the microsome fraction of adipose tissue is stimulated by epinephrine and norepinephrine. The source of the hormones is the sympathetic nerve endings normally and the adrenal medulla in times of stress.
These hormones activate the cyclase present in adipose tissue that converts adenosine triphosphate (ATP) to cyclic-adenosine monophosphate (AMP). The cyclic nucleotide is the mediator of the hormone action. Cytidine triphosphate (CTP) is also effective in these preparations and may give rise to a cyclic-cytidine derivative. The cyclic nucleotide probably interacts directly with inactive lipase to convert it to an active form. This
Rizack MA. Mechanism of Hormonal Control of Adipose Tissue Lipase.. Ann Intern Med. 1965;62:1077. doi: https://doi.org/10.7326/0003-4819-62-5-1077_2
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Published: Ann Intern Med. 1965;62(5):1077.
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