Julius Wenger, M.D. (Associate); Ivan A. Backerman, M.D.; Joel S. Steinberg, M.D.; Benjamin R. Gendel, M.D., F.A.C.P.
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"A chlorhydria" in pernicious anemia requires more specific definition. Accurate gastric juice collection and pH determination and the choice of proper gastric stimuli are essential.
Fifty-four adult patients with known pernicious anemia were retested for the ability to secrete gastric hydrochloric acid with the newer stimulating techniques. Gastric aspiration by hand suction was performed at 15-minute intervals for 1 hour after a stimulus that was greater than the "standard dose" of histamine. The pH of each specimen was determined with a glass electrode. A fall in pH below 6.0 or a fall in pH of more than 1.0 pH unit
Wenger J, Backerman IA, Steinberg JS, Gendel BR. Studies of Gastric Hydrochloric Acid Secretion in Pernicious Anemia: The Value of Near-maximal Stimulation Techniques.. Ann Intern Med. ;62:1082. doi: 10.7326/0003-4819-62-5-1082_1
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Published: Ann Intern Med. 1965;62(5):1082.
Hematology/Oncology, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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