Paul A. Marks, M.D.
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Hemoglobin synthesis by erythroid cells is a useful model for investigating the mechanisms of cell differentiation and maturation. This will be illustrated, first, by describing studies on the role of polyribosomes in protein synthesis and, in particular, the alterations in polyribosome structure and function that occur as these cells mature and lose capacity to make hemoglobin. Secondly, studies on the mechanisms controlling the formation of hemoglobin A and hemoglobin F will be considered. The conversion from hemoglobin F to A formation in late fetal development and from hemoglobin A to F synthesis in erythroid cells of adults with certain hemolytic
Marks PA. Erythroid Cell Maturation and the Control of Hemoglobin A and F Formation.. Ann Intern Med. 1965;62:1084. doi: https://doi.org/10.7326/0003-4819-62-5-1084_1
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Published: Ann Intern Med. 1965;62(5):1084.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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