Peter R. Galbraith, M.D.; Leslie S. Valberg, M.D.; Peter H. Gruner, M.D.; G. Malcolm Brown, M.D., F.A.C.P.
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Leukokinetic studies were performed in 11 subjects with chronic myelogenous leukemia (CML) by labeling leukocytes in vitro with diisopropyl fluorophosphate and returning them to the circulation. In contrast to normal subjects, in whom leukocytes disappeared in a random fashion with a mean half time (T ½) of 6.44 hours, the average T ½ of CML leukocytes was 106 hours. Normal isologous leukocytes transfused into CML subjects survived normally. Analysis of the leukocyte survival data indicated that the persistance of labeled immature cells could not account for the total amount of leukocyte radioactivity that remained in the blood for prolonged periods.
Galbraith PR, Valberg LS, Gruner PH, et al. The Mechanism of the Leukocytosis in Chronic Myelogenous Leukemia.. Ann Intern Med. 1965;62:1085. doi: https://doi.org/10.7326/0003-4819-62-5-1085_2
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Published: Ann Intern Med. 1965;62(5):1085.
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