William B. Castle, M.D.
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In 1932, pernicious anemia was a unique human disease and only since 1926, no longer a fatal one. Today, vitamin B12 and folic acid, the principal erythropoietic components of liver, have been shown to play fundamental roles as coenzymes in nucleoprotein synthesis in bone marrow and other tissues. In their absence "megablastosis" occurs even in certain bacteria. N15 glycine and ferrokinetics have resolved the controversy concerning maturation arrest and hemolysis as causes of the anemia. In 1936, purified liver extract, effective in pernicious anemia, was shown to be inactive in certain megablastic anemias discovered after 1946 to respond to folic
Castle WB. Pernicious Anemia Then and Now.. Ann Intern Med. 1965;62:1085–1086. doi: 10.7326/0003-4819-62-5-1085_4
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Published: Ann Intern Med. 1965;62(5):1085-1086.
Hematology/Oncology, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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