Robert S. Abernathy, M.D., F.A.C.P.
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It has been proposed that the altered neuromuscular activity in myasthemia gravis results from muscle antibodies formed by auto-immune mechanisms. Auto-antibodies to muscle were therefore searched for in eight patients with myasthemia gravis (MG). By the indirect fluorescent antibody technique, four patients showed binding of their serum gamma globulins to slices of either normal or MG muscle obtained by biopsy. Specific globulin binding was localized to the muscle striations. It was blocked by prior absorption of the serum with muscle but remained after absorption with human liver powder. Diffuse sarcolemmal staining was also seen but was not specific. In three
Abernathy RS. Auto-immunologic Reactions to Muscle in Myasthemia Gravis.. Ann Intern Med. ;62:1087. doi: 10.7326/0003-4819-62-5-1087_1
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Published: Ann Intern Med. 1965;62(5):1087.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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