John H. Bland, M.D., F.A.C.P.; Richard L. Lipson, M.D. (Associate); Fred W. Dunihue, M.D.; Bert K. Kusserow, M.D.; Jackson J. W. Clemmons, M.D.; Leah E. Williams
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Though the Ehler's-Danlos syndrome has a more ancient history than the other genetic disorders of connective tissue, the basic abnormality at a molecular level remains controversial. The present study is a combined biochemical, histological, and chromosomal investigation in four members of a family with Ehler's-Danlos syndrome, a mother and three siblings. They were placed on collagen-free diets for periods of 23 days in 3 patients and 52 days in one patient and the following urinary excretion rates determined daily: hydroxyproline, hexosamine, uronic acid, total nitrogen, creatinine, and uric acid. Daily osmolality measurements were made. Both hydroxyproline and uronic acid excretion
Bland JH, Lipson RL, Dunihue FW, Kusserow BK, Clemmons JJW, Williams LE. A Biochemical, Histological (Light and Electron Microscopy), and Chromosomal Study of a Family with Ehler's-Danlos Syndrome.. Ann Intern Med. 1965;62:1087. doi: 10.7326/0003-4819-62-5-1087_2
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Published: Ann Intern Med. 1965;62(5):1087.
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