Samuel Saslaw, M.D., Ph.D., F.A.C.P.
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In recent years the question has been raised as to whether hypersusceptibility to infection occurs in splenectomized persons. Opinions have differed from clinic to clinic based on many variables including particularly the underlying disease for which splenectomy was performed. Experimental infections in animals have yielded varied results based on agent used and species of animal employed. However, studies in primates have not been adequately investigated. The monkey's anatomy, cellular and humoral responses, and relative spleen size simulates that of man. Thus, studies were conducted in this laboratory to compare the response of normal and splenectomized monkeys to intravenous or aerosol
Saslaw S. Does Splenectomy Predispose to Infection?. Ann Intern Med. 1965;62:1088. doi: https://doi.org/10.7326/0003-4819-62-5-1088_3
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Published: Ann Intern Med. 1965;62(5):1088.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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