Oscar D. Ratnoff, M.D.
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A number of different humoral agents have been implicated in the pathogenesis of inflammation. Histamine, proposed by T. Lewis, increases vascular permeability and dilates blood vessels. Although it can be found in early inflammatory exudates, it cannot be detected at later stages of the inflammatory reaction. The biologically active polypeptide "kinins" increase vascular permeability, dilate blood vessels, induce pain, and attract leukocytes to the site of their injection, suggesting that these agents may also participate in the inflammatory reaction. The kinins may be elaborated in plasma through the action of a proteolytic enzyme, kallikrein. Kallikrein is normally present in plasma
Ratnoff OD. Newer Concepts Concerning Inflammation: Humoral Mechanisms.. Ann Intern Med. 1965;62:1089–1090. doi: https://doi.org/10.7326/0003-4819-62-5-1089_3
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Published: Ann Intern Med. 1965;62(5):1089-1090.
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