Matthew Block, M.D., Ph.D.
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An early and major role in development of immunologic capacity is played by the thymus, which induces development of extrathymic lymphatic tissue and of immunologically competent cells in this tissue. Except possibly for formation of beta 2M immune globulins, antibody formation is restricted to postnatal life in mammals and consists of synthesis of L and H chains and their combination into specific antibodies. After birth lymphatic tissues are self perpetuating, and their maintenance and function is independent of the thymus.
One may postulate abnormalities at any stage in this basically simple scheme. The thymus may not form, or if formed
Block M. Origin and Formation of Immunoglobulin.. Ann Intern Med. 1965;62:1090. doi: https://doi.org/10.7326/0003-4819-62-5-1090_1
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Published: Ann Intern Med. 1965;62(5):1090.
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