Jack Shapiro, M.D.; Chiyo Chiba, M.D.; Norbert Czaikowski, M.D.; Frederick Cushing, M.D.; Melvyn Rosenblatt, M.S.; Paul L. Wolf, M.D.; Richard J. Bing, M.D., F.A.C.P.
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The possibility was explored of establishing a state of active immunity by means of coupling components of autologous body material to an antigenic protein carrier and injecting this complex into the same host from which the material was obtained. Antigenicity of autologous material was produced by diazotization of autologous material with a foreign protein according to the method of Landsteiner. The autologous material thus acted as a haptene and elicited antibodies directed against the same tissue of the same animal. For example, to produce antibodies against the animal's own lymphocytes, lymphoid cells of
a dog were coupled to human gamma
Shapiro J, Chiba C, Czaikowski N, Cushing F, Rosenblatt M, Wolf PL, et al. Production of Enhanced Immunity to Autologous Material by Means of Coupling to an Antigenic Protein Carrier.. Ann Intern Med. ;62:1090. doi: 10.7326/0003-4819-62-5-1090_2
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Published: Ann Intern Med. 1965;62(5):1090.
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