Donald R. Korst, M.D., F.A.C.P.; John C. Nixon, M.D.; Delbert E. Boblitt, M.D.
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A new radiopharmaceutical MHP (Merprane®) binds tightly to erythrocytes resulting in splenic sequestration and subsequent scintillation scanning. Studies in 50 subjects in this report suggests a measure of the sequestration function of the spleen.
Erythrocyte damage by MHP is induced by a concentration of 1.5 mg/ml of blood at a 50% hematocrit reading for 15 to 30 minutes at room temperature results in agglutination in vitro. Whole blood is drawn into a syringe with 50 µc of MHP, heparin, and carrier nonradioactive MHP to a volume of 5 to 10 ml and incubated at room temperature for 30 minutes. After
Korst DR, Nixon JC, Boblitt DE. Spleen Scanning and Function Studies with HG-197 Mercurihydroxypropane (MHP).. Ann Intern Med. 1965;62:1094–1095. doi: https://doi.org/10.7326/0003-4819-62-5-1094_4
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Published: Ann Intern Med. 1965;62(5):1094-1095.
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