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Although it frequently remains unrecognized, disseminated intravascular coagulation is responsible for the manifestations of a wide variety of clinical disorders. This is Dr. McKay's thesis, and he presents with clarity the great body of supporting evidence.
After a brief description of the mechanism of blood clotting, each clinical condition is discussed in which intravascular coagulation may play a significant role along with the evidence favoring this hypothesis. A partial list of these conditions illustrates how broad the implications of the author's thesis are. They include: (1) incompatible blood transfusion reaction, paroxysmal nocturnal hemoglobinuria, sickle cell anemia, thrombohemolytic thrombocytopenic purpura, acquired
Disseminated Intravascular Coagulation; an Intermediary Mechanism of Disease.. Ann Intern Med. 1965;62:1101. doi: 10.7326/0003-4819-62-5-1101_2
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Published: Ann Intern Med. 1965;62(5):1101.
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