SOLOMON POSEN, M.B.; FRANCIS C. NEALE, PH.D.; JOHN S. CLUBB, M.B.
Over the past few years, several attempts have been made to identify the sources of human serum alkaline phosphatase (or phosphatases) by immunological (1), electrophoretic (2-4), or chemical (5) techniques. The methods employed are frequently too cumbersome for routine clinical use, while the results in many instances fail to answer whether, in a given patient, alkaline phosphatase is of hepatic, bony, or other origin. Indeed, some workers (6) have doubted the existence of consistent qualitative differences between the serum enzyme of patients with skeletal disorders and that of patients with hepatic disease and have attributed serum alkaline phosphatase elevation in
POSEN S, NEALE FC, CLUBB JS. Heat Inactivation in the Study of Human Alkaline Phosphatases. Ann Intern Med. ;62:1234–1243. doi: 10.7326/0003-4819-62-6-1234
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Published: Ann Intern Med. 1965;62(6):1234-1243.
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