RICHARD N. PEELER, M.D.; PAUL J. KADULL, M.D.; LEIGHTON E. CLUFF, M.D., F.A.C.P.
Since 1902, when Zenoni (1) first described the occurrence of amyloidosis in horses intensively immunized to diphtheria toxin, there have been numerous reports of animal experiments in which amyloidosis, as well as arteritis and other manifestations of hypersensitivity, have been induced by the injection of many different antigenic agents (2-21). That such adverse reactions to immunization have not been observed in man is doubtlessly related to the relatively trivial doses of antigen to which the human being is usually exposed. The increasing list of antigens recommended for the routine immunization of human beings plus the likelihood that the number of
PEELER RN, KADULL PJ, CLUFF LE. Intensive Immunization of Man: Evaluation of Possible Adverse Consequences. Ann Intern Med. 1965;63:44–57. doi: https://doi.org/10.7326/0003-4819-63-1-44
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Published: Ann Intern Med. 1965;63(1):44-57.
Infectious Disease, Prevention/Screening, Vaccines/Immunization.
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