EUGENE V. BARNETT, M.D.; A. FREDERICK NORTH JR., M.D.; JOHN J. CONDEMI, M.D.; RALPH F. JACOX, M.D.; JOHN H. VAUGHAN, M.D.
Discovery of the lupus erythematosus (LE) cell phenomenon in 1948 by Hargraves, Richmond, and Morton (1) was the first of a series of observations of what have proved to be immunologic phenomena in systemic lupus erythematosus (SLE). In 1950 the serum factor essential for the production of LE cells was identified as a gamma globulin (2). Subsequently the LE cell phenomenon was demonstrated to involve the reaction of white blood cell nucleoprotein (3) and antibody contained in the gamma globulin fraction of SLE sera (4). Several investigators (5, 6-8), utilizing immunofluorescence techniques, detected antinuclear factors in SLE sera capable of
BARNETT EV, NORTH AF, CONDEMI JJ, JACOX RF, VAUGHAN JH. Antinuclear Factors in Systemic Lupus Erythematosus and Rheumatoid Arthritis. Ann Intern Med. 1965;63:100–108. doi: 10.7326/0003-4819-63-1-100
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Published: Ann Intern Med. 1965;63(1):100-108.
Lupus Erythematosus, Rheumatology.
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