P. A. OWREN, M.D.
The rapid increase in the prevalence of coronary heart disease (CHD) in recent decades has frightened the public, alarmed the health authorities, and challenged the medical profession. The fundamental lesion in more than 95% of all cases of CHD is coronary atherosclerosis. This is always a local manifestation of a generalized disease, a universal process that occurs in most humans. It begins in early childhood as fatty streaks and develops into progressive atheroma from the time of adolescence (Figure 1). In some individuals coronary atheroma remains clinically silent for a lifetime, but others are stricken by CHD because of complicating
OWREN PA. Coronary Thrombosis: Its Mechanism and Possible Prevention by Linolenic Acid. Ann Intern Med. 1965;63:167–184. doi: 10.7326/0003-4819-63-2-167
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Published: Ann Intern Med. 1965;63(2):167-184.
Cardiology, Coronary Heart Disease.
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