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Original Research |1 August 1965

Intestinal Lactase Deficiency in Ulcerative Colitis and Regional Ileitis

JOHN E. STRUTHERS JR., M.D.; JOHN W. SINGLETON, M.D.; FRED KERN JR., M.D., F.A.C.P.

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Abstract

Milk intolerance occurs frequently in patients with chronic ulcerative colitis (1, 2) and occasionally in patients with regional ileitis (3). In such patients the ingestion of milk causes an increase in diarrhea and abdominal discomfort, and the withdrawal of milk from the diet is associated with symptomatic improvement. Sensitivity to milk protein has been suggested as the cause of milk intolerance in some patients with chronic ulcerative colitis, supported by the finding of high titers of circulating antibodies to milk proteins (4-6). Recent evidence (3, 7), however, indicates that the concentration of antibody against cow's milk protein is not related

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STRUTHERS JE, SINGLETON JW, KERN F. Intestinal Lactase Deficiency in Ulcerative Colitis and Regional Ileitis. Ann Intern Med. ;63:221–228. doi: 10.7326/0003-4819-63-2-221

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Published: Ann Intern Med. 1965;63(2):221-228.

DOI: 10.7326/0003-4819-63-2-221

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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