CHARLES J. EPSTEIN, M.D.
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In his classic review on Werner's syndrome published in the ANNALS in 1945, Thannhauser (1) was the first to define clearly the essential features of the syndrome and to distinguish it from other conditions (such as scleroderma and Rothmund's syndrome) with which it had been confused. The principal characteristics, as first described by Werner in 1904 (2) and expanded by Thannhauser and others (1, 3-6), are  shortness of stature,  cataracts,  skin changes affecting mainly the legs and consisting of atrophy, tightening, hyperkeratoses, and ulcers,  premature graying and loss of hair, and  atrophy of the muscle,
EPSTEIN CJ. Werner's Syndrome. Ann Intern Med. 1965;63:343–345. doi: https://doi.org/10.7326/0003-4819-63-2-343
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Published: Ann Intern Med. 1965;63(2):343-345.
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