PETER KORNFELD, M.D., F.A.C.P.; SHEPPARD SIEGAL, M.D., F.A.C.P.; LEE BURNETT WEINER, PH.D.; KERMIT E. OSSERMAN, M.D., F.A.C.P.
It has recently been suggested that myasthenia gravis may be an autoimmune disease (1-3). This hypothesis is supported by  the presence of abnormal antibodies in myasthenic patients such as serum globulins reacting with skeletal, cardiac muscle, and epithelial cells of the thymus, antinuclear factors, and thyroglobulin antibodies (4-7);  correlations between fluctuations in serum complement levels and clinical course of the disease (1);  passage of a possible transplacental factor from myasthenic mother to newborn baby (8);  high incidence of thymoma and thymic hyperplasia with and without germinal centers (9). The literature contains many reports on the coexistence
KORNFELD P, SIEGAL S, WEINER LB, OSSERMAN KE. Studies in Myasthenia Gravis: Immunologic Response in Thymectomized and Nonthymectomized Patients. Ann Intern Med. 1965;63:416–428. doi: 10.7326/0003-4819-63-3-416
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Published: Ann Intern Med. 1965;63(3):416-428.
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