ROBERT H. WILLIAMS, M.D., F.A.C.P.
In most patients with diabetes mellitus, the primary fundamental defect has not been elucidated, but there is much to indicate that it is on a hereditary basis. Many individuals destined to develop the disease do not manifest hyperglycemia, glycosuria, and other classic features until many years after birth. Most individuals studied have been found to show various types of microvascular histological changes (1) before they manifest overt abnormalities in blood sugar. Since insulin corrects many of the abnormalities in diabetes, major attention, of course, has been given to the consideration that diabetes is associated with insulin deficiency, and indeed under
WILLIAMS RH. Recent Advances Relative to Diabetes Mellitus. Ann Intern Med. ;63:512–529. doi: 10.7326/0003-4819-63-3-512
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Published: Ann Intern Med. 1965;63(3):512-529.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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