H. BERNHARDT, M.D.; L. L. BURKETT, M.D.; M. L. FIELDS, M.D.; J. KILLIAN
The subject of auto-antibodies in pernicious anemia and the auto-immune nature of this disease is presented lucidly in recent publications by Doniach and Roitt (1) and Irvine (2). Serological tests have revealed two distinct antibodies in pernicious anemia, one reactive with intrinsic factor (3, 4) and the other against saline extracts of gastric homogenates (5). The mitochondrial-microsomal fraction of gastric fundal mucosa was found to be a better antigen than the crude saline extracts (6).
While attempts to demonstrate intrinsic factor antibodies by immunofluorescence have been unsuccessful, antibodies to gastric parietal cells have been readily shown in a high percentage
BERNHARDT H, BURKETT LL, FIELDS ML, KILLIAN J. The Diagnostic Significance of the Parietal Cell Immunofluorescent Test. Ann Intern Med. 1965;63:635–641. doi: 10.7326/0003-4819-63-4-635
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Published: Ann Intern Med. 1965;63(4):635-641.
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