ROBERT E. KRAVETZ, M.D.; HOWARD M. SPIRO, M.D., F.A.C.P.
The isolation of a potent gastrin like gastric secretagogue from the nonbeta cell tumor of the pancreas by Gregory, Tracy, French, and Sircus (1) has provided an explanation for the gastric hypersecretion and multiple peptic ulcerations in patients with the Zollinger-Ellison syndrome. Attention is now turning to the role of the normal pancreas in the control of gastric secretion. It would seem reasonable to conclude that if the tumor contains a gastric secretagogue, the normal pancreas might also contain this hormone although perhaps in smaller amounts. Several groups, however, have consistently failed to find a humoral stimulant of gastric secretion
KRAVETZ RE, SPIRO HM. Gastric Secretion in Chronic Pancreatitis. Ann Intern Med. 1965;63:776–782. doi: 10.7326/0003-4819-63-5-776
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Published: Ann Intern Med. 1965;63(5):776-782.
Gastroenterology/Hepatology, Pancreatic Disease.
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