Jay N. Cohn, M.D.; Myron H. Luria, M.D.
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Clinical hypotension and shock in the absence of blood loss often is characterized by low or normal right atrial pressure and low cardiac output. A rapid infusion of 500 ml dextran in 19 patients with this hemodynamic pattern resulted in marked clinical and circulatory improvement. Arterial pressure rose from an average of 80/45 to 113/59 mm Hg; cardiac output increased from an average of 3.1 to 5.8 liters/min; and peripheral vascular resistance fell from a mean of 1,637 to 1,035 dynes sec/cm5. The signs and symptoms of shock were reversed in many of the patients. Clinical diagnoses in these patients
Cohn JN, Luria MH. Hemodynamic and Clinical Effects of Dextran in Nonhemorrhagic Shock in Man.. Ann Intern Med. 1965;63:904. doi: https://doi.org/10.7326/0003-4819-63-5-904_2
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Published: Ann Intern Med. 1965;63(5):904.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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