Albert G. Vitale, M.D.; John L. Soscia, M.D.
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Approximately 12% of patients with symptomatic rheumatic mitral valvular disease present with pulmonary artery pressure or pulmonary vascular resistance values approximating those found at the systemic level. This group of patients exhibits a rather remarkable clinicial syndrome that we have called "malignant pulmonary artery hypertension" in mitral valvular disease. A detailed analysis of the natural history, physical findings, physiologic, and radiologic data are presented on ten patients with this syndrome.
All patients had either a pulmonary systolic pre ssure of 100 mm Hg or a pulmonary arteriolar resistance of 800 dynes/sec/cm-5 or greater at rest. The highest values recorded were 192/63
Vitale AG, Soscia JL. Malignant Pulmonary Artery Hypertension in Rheumatic Mitral Valvular Disease.. Ann Intern Med. 1965;63:905. doi: https://doi.org/10.7326/0003-4819-63-5-905_1
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Published: Ann Intern Med. 1965;63(5):905.
Cardiology, Pulmonary Hypertension, Pulmonary/Critical Care, Rheumatology, Valvular Heart Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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