Morton J. Oppenheimer, M.D.; Guido Ascanio, M.D.; Frank Barrera, M.D.; Elizabeth V. Lautsch, M.D.
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Acute necrobiosis of localized areas of myocardium was produced by injection of hexachlorotetrafluorobutane (Hexa) into the left circumflex coronary artery of nonthoracotomized, anesthetized dogs. Significant hemodynamic observations included bradycardia, decrease in left ventricular systolic pressure, decrease in the first derivative of left ventricular pressure pulse, and systemic hypotension. Decreased cardiac output and decreased peripheral resistance were also observed. Ventricular fibrillation caused death in 50% of the dogs. Norepinephrine levels of noninfarcted myocardium were normal; infarcted areas were depleted.
Dogs pretreated with reserpine were almost completely protected against the hemodynamic changes due to Hexa such as were observed in untreated animals.
Oppenheimer MJ, Ascanio G, Barrera F, Lautsch EV. Role of Inhibitory Reflexes in the Hypotension Attendant on Acute Coronary Necrosis.. Ann Intern Med. 1965;63:907. doi: 10.7326/0003-4819-63-5-907_1
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Published: Ann Intern Med. 1965;63(5):907.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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