Milford Fulop, M.D.; John Sandson, M.D.; Paul Brazeau, Ph.D.
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Plasma conjugated and unconjugated bilirubin were both believed to be completely protein-bound and hence unavailable for renal glomerular filtration. Our studies in dogs with ligated common bile ducts, however, suggested that glomerular filtration was the predominant mechanism of renal excretion of conjugated bilirubin. The binding of bilirubin to plasma proteins was therefore reexamined. Unconjugated bilirubin was not dialyzable from plasma. Dialysis of conjugated hyperbilirubinemic plasma did yield a small fraction of dialyzable bilirubin, sufficient to account for its renal excretion by glomerular filtration. This dialyzable plasma fraction increased in jaundiced patients who developed renal insufficiency. Paper electrophoresis of unconjugated hyperbilirubinemic
Fulop M, Sandson J, Brazeau P. The Renal Excretion of Bilirubin in Man.. Ann Intern Med. 1965;63:910. doi: https://doi.org/10.7326/0003-4819-63-5-910_3
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Published: Ann Intern Med. 1965;63(5):910.
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