John W. Yarbro, M.D. (Associate); Paul Engstrom, M.D.; B. J. Kennedy, M.D., F.A.C.P.
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Hydroxyurea is effective against a variety of neoplasms. During the administration of this agent, bone marrow suppression occurred as manifested by a decrease in reticulocytes, leukopenia, thrombocytopenia, and anemia. Most significantly, a marked megaloblastosis was observed during and immediately after the administration of hydroxyurea. Because of the relationship between megaloblastosis and nucleic acid metabolism, an investigation of this phenomena was undertaken by a study of the effect of hydroxyurea on nucleic acid metabolism in a transplantable ascites tumor in C3M mice. Nucleic acid synthesis was determined by means of incorporation of P32 orthophosphate into deoxyribonucleic acid (DNA) and ribonucleic acid
Yarbro JW, Engstrom P, Kennedy BJ. DNA Inhibition as an Explanation of Hydroxyurea Induced Megaloblastosis.. Ann Intern Med. 1965;63:917. doi: https://doi.org/10.7326/0003-4819-63-5-917_1
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Published: Ann Intern Med. 1965;63(5):917.
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