Manuel Ochoa Jr., M.D.; I. B. Weinstein, M.D.
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The escape from host control characteristic of tumor cells may reflect changes in the mechanism of protein synthesis or alterations in the genetic code. The present study compares normal and neoplastic cells with respect to amino acid coding and the biochemical steps in protein synthesis.
As in Escherichia coli, protein synthesis by extracts from human chronic lymphocytic leukemia, mouse L1210 leukemia, a human plasma cell tumor, the rat MtT/W5 mammosomatotropic pituitary tumor, rabbit reticulocytes, and normal rat liver could be redirected by synthetic messenger ribonucleic acid (RNA) (mRNA). A group of synthetic mRNAs, differing in their base compositions, have been
Ochoa M, Weinstein IB. Protein Synthesis and the Genetic Code in Subcellular Systems Derived from Normal and Neoplastic Animal and Human Tissues.. Ann Intern Med. ;63:917–918. doi: 10.7326/0003-4819-63-5-917_3
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Published: Ann Intern Med. 1965;63(5):917-918.
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