Henry E. Wilson, M.D., F.A.C.P.; John Louis, M.D., F.A.C.P.
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The introduction of the nitrogen mustard compounds in the treatment of neoplastic disease opened the field of modern cancer chemotherapy and established the therapeutic effectiveness of these compounds when administered in intermittent large dosage regimens. Such dosage regimens almost invariably produced significant degrees of toxicity. Favorable tumor responses to other suppressive agents administered in similar intermittent large dosage regimens have gone far toward almost standardizing this therapeutic approach in the treatment of malignant disease.
Recent experience has demonstrated that equal or superior responses can be achieved with some compounds when they are administered in continuous low dosage regimens with minimal
Wilson HE, Louis J. The Use of Low Dosage Drug Regimens in the Treatments of Neoplastic Disease.. Ann Intern Med. 1965;63:918. doi: https://doi.org/10.7326/0003-4819-63-5-918_1
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Published: Ann Intern Med. 1965;63(5):918.
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