MICHAEL J. BRENNAN, M.D., F.A.C.P.
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Diagnosis of disease through the detailed morphological examination of cell suspensions spread on glass has been practiced by internists for 80 years. Recognition of the unique morphological character of the megaloblast of pernicious anemia by Ehrlich, Pappenheim, and Naegeli in the 1880's instituted the era of clinical diagnosis based upon specific cytostructural features of individual cells. Arinkin's demonstration of the feasibility of sternal marrow aspiration in 1927 led to further applications of cytostructural diagnosis in clinical medicine, particularly in the leukemias, the lymphomata, and multiple myeloma, as well as in Gaucher's and in Niemann-Pick's disease. Still later, lupus erythematosus disseminata
BRENNAN MJ. Cytological Diagnosis. Ann Intern Med. ;63:1155–1159. doi: 10.7326/0003-4819-63-6-1155
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Published: Ann Intern Med. 1965;63(6):1155-1159.
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