M. J. CAWEIN, M.D.; E. J. LAPPAT, M.D.; R. W. BRANGLE, M.D.; C. H. FARLEY, M.D.
Itano (1) first described hemoglobin D in 1951 in a Caucasian family who had hemoglobin S interacting with D. Hemoglobin D was the fifth hemoglobin to be described. To date, 11 cases of hemoglobin S-D disease have been reported in the literature. It is the purpose of this paper to report four additional cases of hemoglobin S-D disease in unrelated Negro families. Since patients with hemoglobin S-D disease present with anemia, circulating sickle cells in the venous blood, and a hemoglobin that migrates with hemoglobin S on paper electrophoresis at pH 8.6, they are frequently diagnosed as sickle cell anemia.
CAWEIN MJ, LAPPAT EJ, BRANGLE RW, FARLEY CH. Hemoglobin S-D Disease. Ann Intern Med. ;64:62–70. doi: 10.7326/0003-4819-64-1-62
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Published: Ann Intern Med. 1966;64(1):62-70.
Hematology/Oncology, Red Cell Disorders.
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