WILLIAM E. RAWLS, M.D.; PETER J. DYCK, M.D.; DONALD W. KLASS, M.D.; HUGH D. GREER III, M.D.; ERNEST C. HERRMANN JR., PH.D.
Five patients with fatal encephalitis have come under our observation in a 2-year period. Herpes simplex virus was isolated from the brain in all of these cases. The neurologic picture could be separated into those features common to encephalitis and features related to focal cerebral hemisphere disturbance. The nonspecific symptoms consisted of headache, fever, nuchal rigidity, delirium, and coma. Focal seizures, hemiparesis, aphasia, conjugate eye deviation, and focal electroencephalographic (EEG) and angiographic abnormalities indicated a more focal involvement of the cerebral hemisphere. These focal features in the presence of central nervous system infection made the distinction from cerebral abscess difficult.
RAWLS WE, DYCK PJ, KLASS DW, et al. Encephalitis Associated with Herpes Simplex Virus. Ann Intern Med. 1966;64:104–115. doi: 10.7326/0003-4819-64-1-104
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Published: Ann Intern Med. 1966;64(1):104-115.
CNS Infections, Infectious Disease, Neurology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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