MORTON I. GROSSMAN, M.D.
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During all but the last few of the 60 years that have passed since gastrin was discovered, the major question that concerned authors of papers on this subject was whether the hormone did in fact exist. This question was recently answered definitively when Gregory and his coworkers (1), Anderson and coworkers (2), and Tracy and Gregory (3) isolated gastrin in pure form from the mucosa of the pyloric gland area of the stomach, determined its full chemical structure, and proved the correctness of this structure by total synthesis.
Like the other gastrointestinal hormones, gastrin is a polypeptide. Gastrin derived from
GROSSMAN MI. Gastrin. Ann Intern Med. ;64:212–216. doi: 10.7326/0003-4819-64-1-212
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Published: Ann Intern Med. 1966;64(1):212-216.
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