C. E. BUCKLEY III, M.D.; H. NAGAYA, M.D.; HEBERT O. SIEKER, M.D., F.A.C.P.
The etiology and pathogenesis of sarcoidosis is unknown. Past attempts to demonstrate specific etiologic agents have met with little success. The concept that sarcoidosis occurs only in association with an unusual kind of immunologic responsiveness is not new (1). Many studies of the immunologic response of patients to a variety of agents (2-12) have followed Pinner's (13) suggestion that sarcoid is an anergic form of tuberculosis. Despite demonstrable anergy to tuberculoprotein and other agents that normally provoke delayed hypersensitivity, serologic activity to the same (10) and other antigens often remains intact or hyperactive in patients with sarcoidosis. Various etiologic possibilities
BUCKLEY CE, NAGAYA H, SIEKER HO. Altered Immunologic Activity in Sarcoidosis. Ann Intern Med. 1966;64:508–520. doi: 10.7326/0003-4819-64-3-508
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Published: Ann Intern Med. 1966;64(3):508-520.
Infectious Disease, Mycobacterial Infections.
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