DONALD A. ADAMS, M.D.; ERNEST M. GOLD, M.D.; HARVEY C. GONICK, M.D., F.A.C.P.; MORTON H. MAXWELL, M.D., F.A.C.P.
Corticosteroid therapy regularly suppresses adrenocortical function although upon withdrawal of exogenous steroids restoration of adrenal function is said to occur within several days (1, 2). However, recent evidence indicates that suppression commonly may persist for as long as 6 to 9 months (3). The clinical consequences of this problem are difficult to document other than as isolated reports relating prior steroid treatment to hypotension or sudden death associated with minor trauma or surgical procedures (4-6). The problem of adrenocortical suppression assumes increasing importance now that widespread clinical usage of corticosteroids is approaching 15 treatment years.
Evaluation of intermittent steroid treatment
ADAMS DA, GOLD EM, GONICK HC, et al. Adrenocortical Function During Intermittent Corticosteroid Therapy. Ann Intern Med. 1966;64:542–551. doi: 10.7326/0003-4819-64-3-542
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Published: Ann Intern Med. 1966;64(3):542-551.
Adrenal Disorders, Autoimmune Kidney Disease, Endocrine and Metabolism, Lupus Erythematosus, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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